Abrupt stopping steroids

Corticosteroids can produce reversible hypothalamic- pituitary adrenal (HPA) axis suppression with the potential for corticosteroid insufficiency after withdrawal of treatment. Adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for up to 12 months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. If the patient is receiving steroids already, dosage may have to be increased.

4years ago I had which I now know was PMR. Although never diagnosed at that time I was treated with tapering doses of prednisone and analgesic meds and after 6 mos all symptoms disappeared. Three months ago after a mild URI I came down with the EXACT same symptoms a frustrating condition! Only abnormal tests were very high sed rate and C-reactive proteins which are indicative of edema,along with a mild anemia. Went back to the same Drs who were perplexed as to why I had this 4 year remission until I went to a new Rheumatologist ( previous one had retired) who finally diagnosed PMR. 24 hours after the first dose of steroid(40mg) I was 85% better. I am now on a tapering dose currently 20mg and take acetaminophen at regular 4 hour intervals( being. Careful not to exceed 4000mg max per day )
It has given me my life back. I am being followed for side effects of the steroids but the plan is to keep tapering dosage till weaned completely. I know this is not a cure but if it will give me another 4 year respite I will be eternally grateful! (I am now 62yr but first episode was at age 58)

The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile . [22] [23] [24] The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers. [25] They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . [26]

Hypoadrenocorticism is treated with fludrocortisone (trade name Florinef) [35] [36] or a monthly injection of Percorten-V ( desoxycorticosterone pivalate , DOCP) and prednisolone or Zycortal. [37] [38] [39] [40] Routine blood work is necessary in the initial stages until a maintenance dose is established. [8] Most of the medications used in the therapy of hypoadrenocorticism cause excessive thirst and urination. It is absolutely vital to provide fresh drinking water for a canine suffering from this disorder. [12]

I have been on Methimazole  5 mg for about 6 months  for hyperthyoid.  My levels go back and forth, but since I have started the methimazole it stays somewhat in the lower range.  The problem is I was losing my hair prior to starting the medication.  After taking for a month or so it seemed to work.  Then it started shedding again slowly so I freaked out and adjusted the dose to 10mg dly.  This helped some with the hair loss.  The labs came back out of range too high so I then stopped taking it for about 3 weeks.  I am now shedding alot!  I started back at 5 mg and now my labs are fine, but I am still losing my hair bad.  What is the problem now?  Labs are good and hair is still shedding?  Please any help would be appreciated ... Thanks 

Abrupt stopping steroids

abrupt stopping steroids

Hypoadrenocorticism is treated with fludrocortisone (trade name Florinef) [35] [36] or a monthly injection of Percorten-V ( desoxycorticosterone pivalate , DOCP) and prednisolone or Zycortal. [37] [38] [39] [40] Routine blood work is necessary in the initial stages until a maintenance dose is established. [8] Most of the medications used in the therapy of hypoadrenocorticism cause excessive thirst and urination. It is absolutely vital to provide fresh drinking water for a canine suffering from this disorder. [12]

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