Omega-3 fatty acids have been shown to disrupt inflammation cell signaling pathways by binding to the GPR120 receptor.  This benefit however can be inhibited or even reversed if the ratio of Omega-6 / Omega-3 is too high as Omega-6 serves as a precursor to inflammatory chemicals ( prostaglandin and leukotriene eicosanoids ) in the body.   A high proportion of omega-6 to omega-3 fat in the diet shifts the physiological state in the tissues toward the pathogenesis of many diseases: prothrombotic, proinflammatory and proconstrictive.  Omega-6 competes with Omega-3 for the same rate limiting factor which is required for the health-benefits of Omega-3, directly reducing the action of Omega-3 in addition to pharmacologically counteracting Omega-3 benefits through its own action as a pro-inflammatory agent.
Upon endocytic PRR binding, actin - myosin cytoskeletal rearrangement adjacent to the plasma membrane occurs in a way that endocytoses the plasma membrane containing the PRR-PAMP complex, and the microbe. Phosphatidylinositol and Vps34 - Vps15 - Beclin1 signalling pathways have been implicated to traffic the endocytosed phagosome to intracellular lysosomes , where fusion of the phagosome and the lysosome produces a phagolysosome. The reactive oxygen species , superoxides and hypochlorite bleach within the phagolysosomes then kill microbes inside the phagocyte.
Peppers are an anti-inflammatory superfood—but go red to reap the most benefits. Out of the three colors of bell pepper, red have the highest amount of inflammatory-biomarker-reducing vitamin C along with the bioflavonoids beta-carotene, quercetin, and luteolin, according to research in the Journal of Food Science . Luteolin has been found to neutralize free radicals and reduce inflammation. Beta-carotene is a carotenoid, fat-soluble compounds that are associated with a reduction in a wide range of cancers, as well as reduced risk and severity of inflammatory conditions such as asthma and rheumatoid arthritis. And allergy research has shown that quercetin acts as a mast-cell stabilizer, which decreases the number of cells reacting to an allergen. Mast cells are responsible for releasing histamine during inflammatory and allergic reactions.