Corticosteroid side effects during pregnancy

Methotrexate is given weekly as an intramuscular injection of 15 to 25 mg. Side effects are rare and include leukopenia and hypersensitivity interstitial pneumonitis. Hepatic fibrosis is the most severe potential sequela of long-term therapy. Patients with concomitant alcohol abuse and/or morbid obesity are more likely to develop hepatic fibrosis and therefore should not be treated with methotrexate. It is prudent to obtain a baseline chest radiograph and to monitor complete blood count, liver function and renal function every two weeks until the patient is receiving oral therapy, and every one to three months thereafter. Before methotrexate therapy is initiated, the risks of treatment and the possible need for a liver biopsy should be discussed with the patient.

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  • Citation tools Download this article to citation manager Crawshaw Dickon P , Helliwell Philip S , Hensor Elizabeth M A , Hay Elaine M , Aldous Simon J , Conaghan Philip G et al. Exercise therapy after corticosteroid injection for moderate to severe shoulder pain: large pragmatic randomised trial BMJ 2010; 340 :c3037
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    Corticosteroids may interact with a variety of other medicines. When this happens, the effects of one or both of the drugs may change or the risk of side effects may be greater. Anyone who takes corticosteroids should let the physician know all other medicines he or she is taking. Among the drugs that may interact with corticosteroids are:

    • Insulin and diabetes medicines
    • Heart medicine such as digitalis
    • Diuretics (water pills)
    • Medicine containing potassium or sodium
    • Immunizations (vaccinations)
    • Cyclosporine (Sandimmune)
    • Blood thinners, such as warfarin (Coumadin)
    • Estrogen drugs, such as conjugated estrogens (Premarin) or oral contraceptives
    • Antacids (if taken frequently).
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    Corticosteroid side effects during pregnancy

    corticosteroid side effects during pregnancy

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