Hemophilia A can also occur in females because of inheritance of defective F8 genes from both parents or on the basis of an autosome translocation disrupting the structure of the gene (., Migeon et al., 1989 ). Pola and Svojitka (1957) reported a homozygous affected female who was the daughter of a hemophilic man married to a double first cousin. Sie et al. (1985) reported a homozygous female. In these cases, the homozygous female was not more severely affected than the hemizygous male. Theoretically, a female can be homozygous on the basis of uniparental isodisomy. It is also possible, in some cases diagnosed as hemophilia A, that actually von Willebrand disease (see 193400 ) is producing the hemorrhagic diathesis with very low levels of factor VIII.
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