Reasons for treatment of bladder stones include recurring symptoms and risk of urinary tract obstruction. Some stones can be dissolved using dietary modifications and/or medications. Small stones in female dogs may possibly be removed by urohydropropulsion , a nonsurgical procedure. Urohydropropulsion is performed under sedation by filling the bladder with saline through a catheter, holding the dog vertically, and squeezing the bladder to expel the stones through the urethra. Bladder stones can be removed surgically by a cystotomy , opening of the bladder. Stones lodged in the urethra can often be flushed into the bladder and removed, but sometimes a urethrotomy is necessary. In male dogs with recurrent urinary tract obstruction a scrotal urethrostomy creates a permanent opening in the urethra proximal to the area where most stones lodge, behind the os penis . In male cats, stones lodge where the urethra narrows in the penis. Recurrent cases can be treated surgically with a perineal urethrostomy , which removes the penis and creates a new opening for the urethra.
It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
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